Meeting Information

NCATS Workshop on Translational Challenges of Induced Pluripotent Stem Cells

Date: September 26, 2017

Time: 8:15 a.m. - 5:00 p.m. ET

Location:

Lister Hill Center Auditorium
Lister Hill National Center for Biomedical Communications
National Library of Medicine, Building 38A
National Institutes of Health
8600 Rockville Pike
Bethesda, Maryland 20894

Overview: 

The discovery of induced pluripotent stem cells (iPSCs) more than a decade ago has transformed stem cell biology and biomedical research in such fields as disease modeling, drug discovery, predictive toxicology and regenerative medicine applications. To bring iPSC-based therapies more efficiently to patients, it is pivotal to continue addressing the key knowledge gaps and roadblocks in a coordinated multidisciplinary fashion. This workshop will focus on defining the collaborative opportunities, challenges and best practices in translational iPSC research. Topics of interest are quality control standards for pluripotency, safety, experimental reproducibility, cost-efficient scalability and manufacturing, improved and efficient differentiation protocols, advances in -omics and functional characterization of cell-type identities, and other relevant questions. As a deliverable of the workshop, the gathered information and recommendations will help to draft a white paper for the translational stem cell community.

Workshop Objectives:

  • Highlight the biological and technological challenges of advancing induced pluripotent stem cells (iPSCs) into clinical applications and drug discover;
  • Evaluate the state-of-the field of iPSC translation and discuss critical steps for quality control, standardization and reproducibility;
  • Discuss methods of protocol development/optimization and molecular and functional analyses; and
  • Seek input from experts on areas of prioritization and tractable strategies for the iPSC field.

Key Audiences:

  • Stem Cell and developmental biologists
  • Translational scientists
  • Cell and molecular biologists
  • Drug discovery scientists
  • NIH intramural and extramural postdoctoral trainees

Topic Areas:

  • iPSC and clinical translation
  • Cell differentiation and molecular characterization
  • Cell maturation and functional analysis
  • Quality control, standardization and safety of iPSC technologies

Confirmed Speakers:

  • Christine Mummery, Ph.D., Leiden University
  • Kapil Bharti, Ph.D., National Eye Institute, National Institutes of Health (NIH)
  • Patrick Cahan, Ph.D., Johns Hopkins University
  • Nathan Coussens, Ph.D., National Center for Advancing Translational Sciences (NCATS), NIH
  • Stephen Duncan, D.Phil., Medical University South Carolina
  • Lydia Finley, Ph.D., Memorial Sloan Kettering Center Center 
  • Jan Jensen, Ph.D., Cleveland Clinic & Trailhead Biosystems
  • Wei Liang, Ph.D., Food and Drug Administration
  • Scott Noggle, Ph.D., New York Stem Cell Foundation
  • In-Hyun Park, Ph.D., Yale University
  • Thorsten Schlaeger, Ph.D., Boston Children's Hospital
  • Michael Sheldon, Ph.D., Rutgers University
  • Ilyas Singec, M.D., Ph.D., NCATS, NIH - Scientific Meeting Organizer

 

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